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  Home::Protective action of Quercetin on NCV in Streptozotocin induced diabetes in rats: reinforcement by v
  Protective action of Quercetin on NCV in Streptozotocin induced diabetes in rats: reinforcement by v

Hyperglycemia-induced oxidative stress makes an important contribution to the etiology of diabetic neuropathy. Elevated reactive oxygen species (ROS) cause cumulative damage to neurons and Schwan cells, however, they also have a deleterious effect on nerve blood flow causing endoneurial hypoxia, which is responsible for early nerve conduction velocity (NCV) deficits and contributes to an increase in resistance to ischemic conduction failure (RICF).We tested whether antioxidants-Quercetin, vitamin E or the combination of these drugs, could prevent the early signs of neural dysfunction in animal model of diabetes in 8-9 weeks old male Wistar rats, made diabetic by Streptozotocin (65 mg/kg, i.p.) 4 months prior to testing. Neuropathy was evaluated electrophysiologically by measuring motor NCV and RICF of sciatic nerve in vitro. We observed that treatment with the combination of Quercetin and vitamin E significantly (p < 0.001) reduced the NCV slowing in diabetic rats, although it did not fully prevent the NCV impairment. Significant effect (p < 0.05) was also observed in Quercetin monotherapy. The RICF elevated in diabetic animals was not affected by any drug applied. This study confirmed that treatment with appropriate antioxidants, especially their combination could partially prevent the decrease in NCV in diabetic rats.

Date: 15, Sep 2012 Posted By: admin
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