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  Home::Spectrophotometric Assay of Levofloxacin content in some Marketed Generics in Nigeria using the Grap
  Spectrophotometric Assay of Levofloxacin content in some Marketed Generics in Nigeria using the Grap
   

This present study is aimed at the determination of the content of levofloxacin in nine marketed generics (coded L1-L9) in Nigeria. Content of active determination was done using the method of Vipul and Afieroho et.al (2011). The graphical and standard comparison approaches were used. Tablet weight variation, and TLC examination was done using standard procedures. TLC examination showed that all the nine brands contained levofloxacin Rf 0.53. Except for three L6, L7 and L8, the content of levofloxacin in the selected brands were within the allowable 90-110 % limits for tablets using either the graphical or standard comparison approach with no observed significant difference p> 0.05. Non conformity with pharmacopoeia standards was observed in the weight uniformity results for three brands L3, L4 and L8. The result while further validating the recovery accuracy of the method also indicated the need for improved and strict regulation of formulated pharmaceutical products by the regulatory authorities in Nigeria to ensure product quality and safety.

Date: 11, Dec 2012 Posted By: admin
   
 
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