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  Home::AN OVERVIEW ON CEFTRIAXONE SODIUM
  AN OVERVIEW ON CEFTRIAXONE SODIUM
   

The cephalosporins such as cefuroxime, cefotiam and cefotaxime are antibiotics that have been in clinical use for many years. Ceftriaxone sodium (trade name- Rocephin) is also a broad-spectrum antibiotic comes under third generation of cephalosporins. The di-sodium of Ceftriaxone was synthesized from 7-aminocephalosporintriazine (7-ACT) substituted by triazine at 3-position of 7-aminocephalosporin (7-ACA) and active ester which is reacted with amino thiazoleacetic acid and bis-benzothiazole-disulfide. It is active against for both gram-positive and gram-negative bacteria but has expanded activity against gram-negative bacteria. It is used to treat serious infections, it is prescribed for infections of the lower respiratory tract, urinary tract, skin, abdomen, bones, and joints, to treat gonorrhea, septicemia, meningitis and in surgical prophylaxis, particularly in coronary bypass operations. Ceftriaxone have a long half-life in the body and thus offer the advantage of reduced frequency of dosage.

Date: 13, Dec 2012 Posted By: admin
   
 
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