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  Home::Effect of Methanol Extract of Garcinia Kola Stem Bark on Gastric Acid Secretion and Ulcer Models
  Effect of Methanol Extract of Garcinia Kola Stem Bark on Gastric Acid Secretion and Ulcer Models

Garcinia kola stem bark (GSB) is used by traditional birth attendants in Ogoni, Nigeria to treat dysmenorrhoea. GSB has been pharmacologically proven to have analgesic and anti-inflammatory properties. In the light of the fact that commonly used non-steroidal anti-inflammatory drugs are ulcerogenic, the methanol extract of GSB was investigated on experimentally induced ulcers and on gastric acid secretion in rats. Ulceration was induced with ethanol, indomethacin and reserpine respectively. The parameters for ulcer assessment were degree of ulceration, total ulcer scores and ulcer index. The treatment groups consisted of three doses of GSB: 18, 36 and 72 mg/kg, p.o. respectively; cimetidine (100 mg/kg; p.o.) and a group treated with cimetidine (100 mg/kg; p.o) and the extract (36 mg/kg p.o.) 10min later. The extract produced significant (p < 0.05 0.001), dose dependent inhibition of ulcers (reduction in ulcer index values) relative to control, in all three models, however, the extent of ulcer inhibition of the extract was lower than that of cimetidine in all the models, and a combination of the extract with cimetidine produced an enhanced ulcer-inhibitory property. Furthermore, the effect of the extract on gastric acid secretion showed that the secretion was not significantly affected by the extract, relative to control. This study therefore suggest that G. kola stem bark, which is known to have analgesic and anti-inflammatory properties, as stated earlier, also has ulcer-reducing properties which may not be related to any effect on gastric acid secretion.

Date: 13, Dec 2012 Posted By: admin
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