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  Home::FORMULATION AND IN VITRO EVALUATION OF ACE INHIBITOR ENALAPRIL CONTAINING TRANSDERMAL FILMS
  FORMULATION AND IN VITRO EVALUATION OF ACE INHIBITOR ENALAPRIL CONTAINING TRANSDERMAL FILMS
   

The present study was planned to develop and evaluate transdermal matrix films of enalapril maleate employing various polymers to achieve controlled release. Preformulation and compatibility studies of drug and polymers were carried out. Matrix transdermal films using ethyl cellulose and co-povidone were formulated and evaluated for physicochemical properties, water vapour transmission studies and drug content estimation. The in vitro release through rat abdominal skin using Keshary-Chien diffusion cell and influence of different polymers on drug release profiles was investigated. The concentration of polymers on drug release characteristics was studied followed by skin irritation test for selected films. Thin, flexible, smooth and transparent films were obtained with EC alone, blends of EC: PVP and EC:copovidone film. FT-IR and DSC studies confirmed no interaction between the drug and polymers. Thickness, mass, folding endurance and drug content were found to be uniform and reproducible with low SD values. Water vapour transmission (WVT) through drug free transdermal films followed zero order kinetics. All the films sustained and prolonged release of EM up to 24 h. The drug release rate was increased with the increased hydrophilic polymer. The highest drug release was observed with F6 EC:copovidone 5:5 ratio 81.32%. The release of the EM was higuchi model with non-fickian diffusion controlled drug release. The film F6 did not show skin irritation indicated their safety for topical application.From the overall studies it could be concluded that the polymeric matrix-type transdermal films of EM prepared to avoid first pass metabolism of drug and improve patient compliance.

Date: 13, Dec 2012 Posted By: admin
   
 
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