Search Journals
 
Wednesday, September 22, 11:45:00 AM
 
  Home::STUDIES ON DESIGN AND DERMAL EVALUATION OF ACE INHIBITOR FILMS
  STUDIES ON DESIGN AND DERMAL EVALUATION OF ACE INHIBITOR FILMS
   

Monolithic transdermal matrix films of Enalapril were formulated to avoid first pass effect and to achieve controlled release using Eudragit RL 100 and Copovidone polymers by solvent casting method. Dibutyl phthalate was used as plasticizer. The formulations were evaluated for physical appearance, thickness uniformity, weight uniformity, drug content uniformity and water vapour transmission rate. The in vitro drug release from the films was studied by using Keshary Chein diffusion cell through excised rat abdominal skin and influence of polymers on drug release profiles was investigated. Permeation parameters like diffusion rate, permeability coefficient, flux, enhancement ratio and permeability rate were determined. FT-IR and DSC studies confirmed no interaction between the drug and polymers. Thin, flexible, smooth and transparent films were obtained with Eudragit RL 100 alone, blends of Eudragit RL 100: Copovidone. The physicochemical properties of all films were found to be uniform and reproducible with low SD values. Water vapour transmission followed zero order release. All the films sustained and prolonged release of EM up to 24 h. All transdermal films n value was ranged from 0.4951 to 0.5590 with correlation coefficient values of 0.9897 to 0.9983 indicated non-fickian diffusion by anomalous controlled diffusion drug release mechanism from all formulations.

Date: 13, Dec 2012 Posted By: admin
   
 
  Login Here
  User Name
 
  Password
 
  Remember Me
  Create an Account
Forgot your login or password?
   
Home | Aim & Scope | Editorial Board | Instructions to Authors | Download | Online Submission | . | Invitation Letter | . |  
Total Visits:
Free website hit counter
Copyright © TGJ. Powered by Web Power India.