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  Home::DEVELOPMENT AND IN VITRO EVALUATION OF VALSARTAN NOVEL DERMAL DRUG DELIVERY SYSTEM
  DEVELOPMENT AND IN VITRO EVALUATION OF VALSARTAN NOVEL DERMAL DRUG DELIVERY SYSTEM
   

Transdermal patches of antihypertensive drug Valsartan with Eudragit RL100, HPMC blends was prepared and evaluated. Transdermal matrix patches of valsartan were prepared by solvent casting method using polymer blends. The fabricated patches were evaluated for their drug content, physicochemical parameters and in vitro studies. Thin, flexible, smooth and transparent patches were obtained. The drug content of all the patches was found to be uniform as indicated by low SD and CV values. Weight and thickness of the patches remained uniform as indicated by low percentage coefficient of variation. The FTIR studied revealed that there was no interaction between drug and polymers. Also SEM showed uniform distrubition of drug with drug molecules dispersed in small aggregates. The in vitro release of the drug remains constant, the release kinetics of the drug followed first order kinetics. The model fitting in all the case was found to be peppas. The experimental results showed that the patch containing HPMC in higher proportion gives increase in release of drug. It indicates that as the concentration of Eudragit RL100 increase, the drug release was decreased. The present study has demonstrated the potential of the Valsartan matrix patch for its prolonged release.

Date: 13, Dec 2012 Posted By: admin
   
 
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