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  Home::EVALUATION OF ANTIUROLITHIC ACTIVITY EFFECT OF EXTRACTS OF ALLIUM CEPA LINN (LILIACEAE)
  EVALUATION OF ANTIUROLITHIC ACTIVITY EFFECT OF EXTRACTS OF ALLIUM CEPA LINN (LILIACEAE)
   

Urolithiasis induced by ethylene glycol is a major problem of modern age. Herbal plants and their constituents are the prime choice of research as they possess better activity and lesser side effects. Allium cepa Linn (Liliaceae) is a plant with diverse medicinal properties; hence the present work was selected to evaluate the antiurolithic activities of aqueous and alcoholic extracts of this plant. Allium cepa was extracted with 75% alcohol by soxhlet apparatus to get alcoholic (AEAC) and water with 10 ml of chloroform as preservative by maceration process to aqueous (AQEAC). Preliminary phytochemical investigations were carried out to identify various phytochemical constituents present in AQEAC and AEAC. The LD50 studies of AQEAC and AEAC were conducted in mice till the highest permitted dose level of 2000 mg/kg following Up and Down method of OECD Guidelines No.425. From the LD50 3 doses of extract as 1/20th (low), 1/10th (medium) and 1/5th (high) were used in the present study. The antiurolithic activity of AQEAC and AEAC was evaluated in laboratory animal models like ethylene glycol induced urolithic model. In urolithiasis animals, a significant (P < 0.01) elevation of serum biochemical parameters like creatinine, uric acid, calcium and physical parameters like kidney wet, dry weights were observed. Pretreatment with AQEAC and AEAC (400 mg/kg) significantly (P < 0.01, P < 0.05) increased serum creatinine, uric acid, calcium and kidney wet, dry weights level, though AQEAC produces better effect than AEAC in rats. Histopathological studies also confirm the protective effect of extracts. The protective effect of Allium cepa was associated with restoration of serum creatinine, uric acid, calcium kidney wet, dry weights levels. Also reduction in the tubular cell derangement and calcium oxalate stones was observed.

Date: 13, Dec 2012 Posted By: admin
   
 
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