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  Home::GASTRORETENTIVE FLOATING IN SITU GEL: AN OVERVIEW
  GASTRORETENTIVE FLOATING IN SITU GEL: AN OVERVIEW
   

The oral delivery of drugs having narrow absorption window in the gastrointestinal tract (GIT) is generally limited by poor bioavailability with conventional dosage forms due to incomplete drug release and short residence time at the site of absorption. To overcome this drawback and to maximize the oral absorption of these drugs, novel drug delivery systems have been designed. Gastroretentive systems such as floating systems, mucoadhesive, high-density, expandable systems have been developed, since they provide controlled delivery of drugs with prolonged gastric residence time. Among all conventional oral dosage forms, liquid orals are more prone to low bioavailability as far as stomach specific drug deliveries are concerned because they of their faster transit from the stomach/ duodenum. To overcome this low bioavailability the in situ gelling system is most beneficial. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. This comprehensive article contains approaches to achieve gastric residence, polymers, evaluation parameter, marketed preparations, some patents, and some research on gastric in situ gel.

Date: 13, Dec 2012 Posted By: admin
   
 
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