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  Home::PRONIOSOMES: A UNIVERSAL CARRIER SYSTEM FOR TRANSDERMAL DELIVERY OF DRUGS
  PRONIOSOMES: A UNIVERSAL CARRIER SYSTEM FOR TRANSDERMAL DELIVERY OF DRUGS
   

The transdermal route is widely used now days as it is convenient over the conventional dosage forms. Niosomes have industrial applicability due to their chemical stability and cost effective materials. Although, niosomes exhibit good chemical stability, they are physically less stable. Aqueous suspension of nisomes exhibit aggregation, fusion, leaking of entrapped drug thus reduces shelf life of dispersion. Hence, ‘dry niosomes’ can be prepared which are often called as ‘Proniosomes’ avoids many problems associated with niosomes like physical stability. proniosomes can be hydrated immediately before use to give niosomal dispersion. Proniosomes are dry, free flowing granular product which upon hydration gives a multilamellar niosomal dispersion. Approaches to stabilize niosomal drug delivery system without affecting its properties of merits have resulted in the development of the promising drug carrier, proniosomes. Proniosomes is dry formulation using suitable carrier coated with non ionic surfactants and can be converted into niosomes immediately before use by hydration. These proniosome-derived niosomes are as good as or even better than conventional niosome. The focus of this review is to bring out different aspects related to proniosomes preparation, characterization, entrapment efficiency, in vitro drug release, applications and merits.

Date: 13, Dec 2012 Posted By: admin
   
 
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