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  Home::BIOCHEMICAL AND HEMATOLOGICAL DYSFUNCTION IN SUBCHRONIC DOSE OF LITHIUM CHLORIDE IN RATS
  BIOCHEMICAL AND HEMATOLOGICAL DYSFUNCTION IN SUBCHRONIC DOSE OF LITHIUM CHLORIDE IN RATS
   

Lithium being used commonly treating mental disorders and bipolar diseases. Long term therapy of lithium may be numerous side effects. Pathogenesis of this lightest alkali metal is needed the mechanism of its physiology. The present study was designed to evaluate the subchronictoxic effect of lithium chloride in male Albino rats. The oral administration of lithium chloride (100 mg/kg body wt) for 21 days through the cannula method elicited a significant alteration in their body weight, lungs and blood biochemical study. Significant (p<0.05) alteration in hematological profiles and liver function test were observed in Li administration. Increased lipid peroxidation and depleted concentration of antioxidant enzymes (super oxide dismutase, catalase and glutathione) were found in both serum and lung tissues of Li treated rats. The results of the present study suggest that lithium potentiate oxidative stress induces toxicity in rat blood as well as in lungs. Moreover, it is also responsible for haematological and hepatological changes in rats. The study will suggest that lithium induced toxicity through the increased rate of production of free radical results oxidative stress.

Date: 13, Dec 2012 Posted By: admin
   
 
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