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Pulmonary drug delivery is a good alternate to deliver drugs, especially protein based drugs directly enters into lung for avoidance of first pass metabolism, minimizing dose size, immediate or prolonged release of drug in a safe and efficacious manner. The drug passes through pharynx, larynx, trachea, primary bronchioles, secondary bronchioles, terminal bronchioles and finally to alveoli. Basically three types of devices are used for pulmonary drug delivery named Pressurized Metered dose inhalers (pMDI), Nebulizer and Dry powdered inhalers (DPI). The pMDI requires chlorofluorocarbon which causes harm to environment, higher price and require special type of filling requirements. Nebulizer requires a pump for the delivery of a drug as a solution. DPIs are more economic and easy to use. These devices are very convenient to carry in purse and pockets. Dry powder inhalers can be used for in several disease conditions like asthma, chronic obstructive pulmonary diseases etc. The main reasons behind popularity of dry powder inhaler use is its low cost, easy use, they do not contai n any propellant, doesn’t require any special filling equipments. They shows rapid onset of action and having less side effects. The particle size should be 1-5µm for dry powder inhalers. Usually lactose is used as carrier-material having particle size 50-150µm instead of other carrier-material like sorbitol, mannitol and glucose. This article focuses on merits, demerits, mechanism of deposition, types of inhalers with main focus on classification of dry powder inhaler, specifications, marketed formulations parameters and their evaluation.

Date: 07, Apr 2013 Posted By: admin
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