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  Home::STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF BOSENTAN IN PHARMACEUTIC
  STABILITY INDICATING LIQUID CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF BOSENTAN IN PHARMACEUTIC
   

A rapid high performance liquid chromatographic method was developed and validated for the determination and stability evaluation of Bosentan in pharmaceutical dosage forms. Separation of Bosentan was successfully achieved on a C-18 column utilizing methanol: Tetra butyl ammonium hydrogen sulphate (10 mM) (80:20, v/v) at a flow rate of 1.2 mL/min and eluate was monitored at 268 nm, with a retention time of 4.425 0.025 mins. The method was validated and the response was found to be linear in the drug concentration range 0.1-250 g/mL with regression equation y = 29905 x + 2312.9 (R2 = 0.9998). The RSD values for precision were found to be 0.2609-0.9132 % (Intra-day) and 0.2231.052 % (Inter-day) respectively. The forced degradation kinetic study of Bosentan by using HCl (0.1N), NaOH (0.1M), H2O2 (6%v/v), thermal (70 2c) and UV radiation (365 nm) were observed to be very specific.

Date: 08, Apr 2013 Posted By: admin
   
 
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