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  Home::Hepatoprotective effect of Abutilon indicum on Carbon Tetrachloride induced Hepatotoxicity
  Hepatoprotective effect of Abutilon indicum on Carbon Tetrachloride induced Hepatotoxicity
   

The aim of the present study was to evaluate the hepato-protective potential of Abutilon indicum (AI). Wistar strain albino rats were used for the investigation of hepato-protective activities of ethanolic (AIE) and aqueous extracts (AIA) of Abutilon indicum (AI). Liver damage was induced by i.p. administration of 30% CCl4 suspended in olive oil (1ml/kg body weight, i.p.). The test drugs and silymarin in the dose of 200 mg/kg body weight were administered by the oral route for a period of 7 days. On the seventh day, except group I (control), all other groups received 30% CCl4 suspended in olive oil (1ml/kg body weight) i.p. On the 8th day, estimations of SGOT, SGPT, ALP, total bilirubin and triglyceride were conducted using diagnostic kits. Intoxication of animals with CCl4 significantly (P <0.001) raised the levels of SGOT, SGPT, ALP and total bilirubin; and decreased the level of triglyceride when compared with normal control group. Treatment with ethanolic and aqueous extracts of AI restored the biochemical parameters towards normal and the results were comparable with reference drug (silymarin). All the biochemical studies were well supported by the histological studies. These studies suggest that Abutilon indicum protects the liver from carbon tetrachloride induced hepatotoxicity.

Date: 08, Apr 2013 Posted By: admin
   
 
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