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  Home::EVALUATION OF ANTI-ANTIASTHMATIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF PHLOGACANTHUS THYRSIFLORUS N
  EVALUATION OF ANTI-ANTIASTHMATIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT OF PHLOGACANTHUS THYRSIFLORUS N
   

In the present study Anti-Asthmatic activity of Hydro-alcoholic Extracts of Phlogacanthus thyrsiflorus leaf were investigated. Anti-Asthmatic activity of Hydroalcoholic Extracts of Phlogacanthus thyrsiflorus were evaluated by Isolated Guinea pig ileum preparation & Histamine induced bronchoconstriction model in experimental rats. The Hydro-alcoholic Extracts of Leaves of Phlogacanthus thyrsiflorus (100 & 200 mg/kg) treat the Asthma and produced significant reductions in (**p<0.01) percent decreased contraction. Standard drug Chlorpheniramine maleate (10μg/ml, p. o) was showed maximum protection against bronchoconstriction in Guinea pigs. The result of present investigation suggested that, Hydro- alcoholic Extract of Phlogacanthus thyrsiflorus have significant bronchodilator activity against histamine. In the present study, the result of Hydro- alcoholic Extract of Phlogacanthus thyrsiflorus (200 mg/kg) significantly protected the Isolated Guinea pig ileum preparation against histamine-induced bronchospasm. The guinea pigs exposed to histamine aerosol showed signs of progressive dyspnoea leading to convulsions. The Hydro- alcoholic Extract of Phlogacanthus thyrsiflorus significantly prolonged the latent period of convulsions (PCT) as compared to control following the exposure of histamine aerosol. In the present study, the Hydro- alcoholic Extract of Phlogacanthus thyrsiflorus leaves exhibited antagonistic activity on both histaminergic and serotonergic receptors.



Date: 17, Aug 2013 Posted By: admin
   
 
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