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  Home::ANTIRETROVIRAL DRUGS: A REVIEW ON PHARMACOKINETIC AND PHARMACODYNAMIC PROFILE
  ANTIRETROVIRAL DRUGS: A REVIEW ON PHARMACOKINETIC AND PHARMACODYNAMIC PROFILE
   

AIDS is Acquired Immunodeficiency Syndrome which begins with Human Immunodeficiency Virus infection and is the final stage of HIV disease. It causes severe damage to the immune system which makes the body susceptible to opportunistic infections. The acute HIV infection progresses over time to asymptomatic infection then early symptomatic infection and finally AIDS. Antiretroviral Drugs (ARV) are the first line drugs for viral suppression and prevention of HIV transmission and so are considered as life saving drugs. No cure is available for it, ARVs suppresses only viral replication. Their maximum adherence is essential for HIV infection management. Antiretroviral drugs are classified into different categories based on the mechanism of blocking HIV at various stages of its life cycle as it enters the host. The classes are NNRTIs, NRTIs, PIs, INSTIs and Fusion inhibitors. In due course of treatment the virus develops resistance to the single drugs and thus there comes a need for the combination therapy or HAART (Highly Active Antiretroviral Therapy). The HAART has ability to overcome the resistance offered by HIV as it contains fixed dose combinations of different drugs. The disease, its prevalence and the drugs with the complete pharmacology are discussed in this review.



Date: 17, Aug 2013 Posted By: admin
   
 
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