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  Home::FORMULATION AND EVALUATION OF SAXAGLIPTIN IMMEDIATE RELEASE AND METFORMIN HYDROCHLORIDE SUSTAINED RE
  FORMULATION AND EVALUATION OF SAXAGLIPTIN IMMEDIATE RELEASE AND METFORMIN HYDROCHLORIDE SUSTAINED RE
   

The objective of the present study was to develop Saxagliptin immediate release and Metformin hydrochloride sustained release tablets formulated employing Hydroxy Propyl Methyl Cellulose polymer and Carmellose sodium polymer, the drug release behavior of the tablets was investigated. Metformin hydrochloride sustained release tablets were prepared by wet granulation methods. The granules were evaluated for bulk density and drug content. The tablets were subjected to Thickness, Dimension, Weight variation test, Hardness, Friability. Saxagliptin was coated to the surface of Metformin hydrochloride sustained release tablets as drug coating. An inner seal coating and outer protective coating optimized to enhance the Saxagliptin drug release and stability of formulation from moister absorbance. Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The results of dissolution studies indicated that formulation F6 the most successful of the study. The results of the dissolution study showed maximum drug release up to 10 hours and the mechanism of the in vitro kinetic release of Metformin hydrochloride was studied by using Zero order, First order, Hixson-Crowell, Higuchi and Korsmeyer-Peppas model. The in vitro release of Metformin hydrochloride sustained release was found diffusion through the swell able matrix polymer. Stability studies of the formulation F6 showing successful formulation of Saxagliptin 2.5mg immediate release and Metformin hydrochloride 500mg sustained release tablets.

Date: 18, Jan 2014 Posted By: admin
   
 
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