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  Home::FORMULATION AND EVALUATION OF FILM COATED TABLETS OF AZITHROMYCIN USP
  FORMULATION AND EVALUATION OF FILM COATED TABLETS OF AZITHROMYCIN USP
   

The present investigation is undertaken with an aim to formulation and evaluation of Film coated tablet of Azithromycin dehydrate. The drug powders were subjected to Preformulation studies. The Preformulation characteristics are within the Pharmacopeial specifications. The drugs and excipients compatibility were carried out by FT-IR studies. The spectra showed that there was no interaction between them. The drugs and excipients compatibility were carried out by HPLC method and by physical observation showed that there was no interaction between them. For Azithromycin dihydrate FC tablets direct granulation was method of choice. Optimization was done and it was found that release profile was found to be best with super-disintegrant i.e. Polyvinyl Pyrrolidine and croscarmellose sodium. Film coating of Protectab HP-1 Sunset yellow Lake IPA coating 3 %w/w was done on Azithromycin dihydrate tablets as to avoid in low humidity condition and geometric mixing is applied to avoid content uniformity and segregation. Results found that release profile of batch no.ADF9 matches with Innovator product. The Percentage cumulative drug release of batch ADF9 was found at 45 Minutes 102.98%.

Date: 18, Jan 2014 Posted By: admin
   
 
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