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  Home::SOLID LIPID NANOPARTICLES - A POTENTIAL DRUG DELIVERY
  SOLID LIPID NANOPARTICLES - A POTENTIAL DRUG DELIVERY
   

Solid lipid nanoparticles (SLN) is an alternative carrier system to traditional colloidal carriers, such as emulsions, liposomes and polymeric micro- and nanoparticles. The SLN combine the advantages (e.g. physical stability, protection of incorporated labile drugs from degradation, controlled release, excellent tolerability) of other traditional colloidal systems. One of the situations in the treatment of disease is the delivery of efficacious medication of appropriate concentration to the site of action in a controlled and continual manner. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. Nanoparticles could be polymeric or lipidic (SLNs). Industry estimates suggest that approximately 40% of lipophilic drug candidates fail due to solubility and formulation stability issues, prompting significant research activity in advanced lipophile delivery technologies. The main goals of Solid Lipid Nanoparticles (SLN) in terms of drug delivery are to increase the bioavailability and efficacy of drugs, to control nonspecific toxicity, immunogenicity, pharmacokinetics and pharmacodynamics of drugs. This review describes the different ways of SLN production such as high pressure homogenization, ultrasonication, solvent emulsification/ evaporation, microemulsion, spray drying and double emulsion method, advantages, characterization and special features.This review focus on, the potential of SLN in various types of chemotherapy such as cancer, parasitic infections and tuberculosis. 



Date: 23, Aug 2012 Posted By: admin
   
 
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