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  Home::SYNERGISTIC, ANTAGONISTIC AND TOXIC EFFECTS OF METALS ON ANTIBIOTICS AS METALLOANTIBIOTICS
  SYNERGISTIC, ANTAGONISTIC AND TOXIC EFFECTS OF METALS ON ANTIBIOTICS AS METALLOANTIBIOTICS
   

Metal complex or coordination compound is a structure consisting of a central metal atom, bonded to a surrounding array of molecules or anions. Many metal complexes have powerful antimicrobial activities and are already in common day-to-day use in medicinal field such as silver bandages for treatment of burns, zinc antiseptic creams, bismuth drugs for the treatment of ulcers and metal clusters as anti-HIV drugs. The chelating properties of metal were used to prepare metal complexes of all the classes of antibiotics as metalloantibiotics. Stability and binding behaviour of metalloantibiotics were studied using Electron Spray Ionisation Mass Spectrometry. Metalloantibiotics can interact with several kinds of biomolecules, including DNA, RNA, proteins, receptors and lipids, making them very unique and specifically. In the search for novel therapy, recent research demonstrated that attaching organic drugs like antibiotics to can enhance their activity. But the results were not always in favour of researchers. Mixed effects of metalloantibiotics were seen. Present review summarizes the synergistic, antagonistic and toxic effects of various metals on complexation with all the classes of antibiotics and provides a base for future synthesis of metalloantibiotics with better stability and desired biological activities.



Date: 23, Aug 2012 Posted By: admin
   
 
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