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  Home::AN INSIGHT OF PARKINSONíS DISEASE- A REVIEW
  AN INSIGHT OF PARKINSONíS DISEASE- A REVIEW
   

Parkinson\'s disease is the second most common neurodegenerative disease after Alzheimer\'s disease. Nevertheless, it has become increasingly evident in recent years that Parkinson\'s disease is a multicentric neurodegenerative process that affects several neuronal structures outside the substantianigra. Parkinson\'s disease is a slowly progressive disorder that affects movement, muscle control, and balance of the body. Dopamine deficiency is the hallmark feature in PD. Loss of dopamine negatively affects the nerves and muscles controlling movement and coordination, resulting in the major symptoms characteristic of Parkinson\'s disease.The characteristic symptoms of Parkinsonís disease like bradykinesia, rigidity tremors and postural instability are generated by loss of dopaminergic neurons. During the early stages of Parkinsonism, it is possible to terminate the symptoms of the disease for awhile. Drugs that are used to do this are known as dopaminergic drugs and anticholinergic drugs used to correct the balance between the neurotransmitters, dopamine and acetylcholine. The more prevalent it has become, the more treatments and surgeries have been discovered or invented. Imaging also provides insights into complications of Parkinson\'s disease and its long-term treatment, and the role of dopamine in the normal brain. Although the symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease.



Date: 23, Aug 2012 Posted By: admin
   
 
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