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  Home::Thiazolidinediones: A Potent Biological Agent
  Thiazolidinediones: A Potent Biological Agent
   

Cardiovascular morbidity and mortality in patients with type 2 diabetes are a major problem in clinical practice. Thiazolidinediones (TZDs) are agonists of the peroxisome proliferator-activated receptor γ which improve glycaemia control by reducing insulin resistance. TZDs also seem to have beneficial effects on various cardiovascular risk factors and consequently may have the potential to reduce the risk of cardiovascular disease (CVD). Although the first large-scale clinical trial evaluating the effect of a TZD on secondary prevention of major adverse cardiovascular outcomes supported this hypothesis, a recently published meta-analysis raised substantial uncertainty about the cardiovascular safety of rosiglitazone. The use of thiazolidinediones (TZDs) in the management of type 2 diabetes mellitus (T2DM) has been associated with an increased risk of peripheral edema. In this article we have depicted the role of Thiazolidinediones on other phenomenal pharmacological activities other than anti-diabetic.



Date: 15, Sep 2012 Posted By: admin
   
 
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