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  Home::In Vitro Free Radical Scavenging and Antioxidant Potential of Methanolic Extract of Euphorbia Neriif
  In Vitro Free Radical Scavenging and Antioxidant Potential of Methanolic Extract of Euphorbia Neriif
   

Cellular damage caused by reactive oxygen species (ROS) has been implicated in several diseases, and hence natural antioxidants have significant importance in human health. The present study was carried out to evaluate the in vitro antioxidant and reactive oxygen species scavenging activities of Euphorbia neriifolia (EN) stem extracts. The methanol extracts were studied for in vitro antioxidant activity along with phenolic contents and reducing power. Scavenging ability of the extracts for radicals like DPPH, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide was also performed to determine the potential of the extracts. EN extract showed the presence of alkaloids, tannins, saponins, flavonoids and cardiac glycosides. Total phenolic content was also measured by standard assay method. The extract showed significant antioxidant activities in a dose dependent manner. The IC50 values for scavenging of free radicals were 85.11 0.53 g/ml, 144.22 2.1 g/ml, 58.10 2.10 g/ml and 25.12 2.71 g/ml for DPPH, nitric oxide, superoxide, hydroxyl radicals respectively. Reductive ability of the extract was also tested where dose dependent reducing capability was observed. The stem extract contains 675.6 g of phenolic compound in 10 mg of the extract which is accounted for its free radical as well as antioxidant activity. From the above study it is concluded that the methanol extract of EN leaves possess antioxidant properties and could serve as free radical inhibitors or scavenger or, acting possibly as natural antioxidants.

Date: 21, Jan 2013 Posted By: admin
   
 
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