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  Home::Stability-Indicating Liquid Chromatographic Method for the determination of Febuxostat in Pharmaceut
  Stability-Indicating Liquid Chromatographic Method for the determination of Febuxostat in Pharmaceut
   

Febuxostat is a selective inhibitor of xanthine oxidase used for the treatment of hyperuricaemia in patients with gout. A simple, fast and robust liquid chromatographic method was developed and validated for the determination of Febuxostat in pharmaceutical formulations using C-18 column with tetra butyl ammonium hydrogen sulphate: acetonitrile (30:70, v/v) as mobile phase and flow rate 1.2 mL/min (UV detection at 216 nm). Linearity was observed in the concentration range of 0.01300 μg/mL (R2 = 0.9999) with regression equation y = 106755 x - 17457. The LOQ was found to be 0.0082 μg/mL and the LOD was found to be 0.0026 μg/mL. Febuxostat was subjected to stress conditions including acidic, alkaline, oxidation and thermal degradation. The method was validated as per ICH guidelines.

Date: 15, Sep 2012 Posted By: admin
   
 
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